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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 9 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Maryna Zanevska | Win | 6-3, 6-2 |
| Second Round | Jodie Burrage | Win | 6-3, 6-2 |
| Third Round | Clara Burel | Win | 6-1, 6-1 |
| Fourth Round | Daria Kasatkina | Win | 6-1, 6-3 |
| Quarterfinals | Qinwen Zheng | Win | 6-1, 6-4 |
| Semifinals | Madison Keys | Win | 0-6, 7-6 (7-1), 7-6 (10-5) |
| Final | Coco Gauff | Loss | 6-2, 3-6, 2-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 20 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ann Li | Win | 7-5, 2-6, 6-4 |
| Third Round | Daria Kasatkina | Win | 6-3, 6-3 |
| Quarterfinals | Ons Jabeur | Win | 7-5, 6-3 |
| Semifinals | Karolina Muchova | Loss | 7-6 (7-4), 3-6, 2-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Petra Martic | Win | 6-3, 7-6 (7-5) |
| Third Round | Liudmila Samsonova | Loss | 6-7 (2-7), 6-4, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 15 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Panna Udvardy | Win | |
| Second Round | Varvara Gracheva | Win | |
| Third Round | Anna Blinkova | Win | |
| Fourth Round | Ekaterina Alexandrova | Win | |
| Quarterfinals | Madison Keys | Win | |
| Semifinals | Ons Jabeur | Loss |
| Bett1 Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Vera Zvonareva | Win | |
| Second Round | Veronika Kudermetova | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 10 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Marta Kostyuk | Win | |
| Second Round | Iryna Shymanovich | Win | |
| Third Round | Kamilla Rakhimova | Win | |
| Fourth Round | Sloane Stephens | Win | |
| Quarterfinals | Elina Svitolina | Win | |
| Semifinals | Karolina Muchova | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 21 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sofia Kenin | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 25 - May 6 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sorana Cirstea | Win | |
| Third Round | Camila Osorio | Win | |
| Fourth Round | Mirra Andreeva | Win | |
| Quarterfinals | Mayar Sherif | Win | |
| Semifinals | Maria Sakkari | Win | |
| Final | Iga Swiatek | Win |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Barbora Krejcikova | Win | |
| Quarterfinals | Paula Badosa | Win | |
| Semifinals | Anastasia Potapova | Win | |
| Final | Iga Swiatek | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 1 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Shelby Rogers | Win | |
| Third Round | Marie Bouzkova | Win | |
| Fourth Round | Barbora Krejcikova | Win | |
| Quarterfinals | Sorana Cirstea | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Evgeniya Rodina | Win | |
| Third Round | Lesia Tsurenko | Win | |
| Fourth Round | Barbora Krejcikova | Win | |
| Quarterfinals | Coco Gauff | Win | |
| Semifinals | Maria Sakkari | Win | |
| Final | Elena Rybakina | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lauren Davis | Win | |
| Third Round | Jelena Ostapenko | Win | |
| Quarterfinals | Barbora Krejcikova | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Tereza Martincova | Win | |
| Second Round | Shelby Rogers | Win | |
| Third Round | Elise Mertens | Win | |
| Fourth Round | Belinda Bencic | Win | |
| Quarterfinals | Donna Vekic | Win | |
| Semifinals | Magda Linette | Win | |
| Final | Elena Rybakina | Win |
| Adelaide International 1 | ||
| Surface: Hard | Date: Dec. 31 - Jan. 8 | Seed: 2 |
| Round | Opponent | W / L | Result |
| Second Round | Liudmila Samsonova | Win | |
| Quarterfinals | Marketa Vondrousova | Win | |
| Semifinals | Irina-Camelia Begu | Win | |
| Final | Linda Noskova | Win |
