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| San Diego Open | ||
| Surface: Hard | Date: Sep. 11 - Sep. 16 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Aliaksandra Sasnovich | Loss | 3-6, 6-3, 2-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 9 | Seed: 15 |
| Round | Opponent | W / L | Result |
| First Round | Kamilla Rakhimova | Win | 6-2, 6-4 |
| Second Round | Yuriko Miyazaki | Win | 6-3, 6-3 |
| Third Round | Lin Zhu | Win | 7-6 (7-1), 2-6, 6-3 |
| Fourth Round | Sorana Cirstea | Loss | 3-6, 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 20 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Cristina Bucsa | Loss | 6-4, 3-6, 2-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Lucia Bronzetti | Win | 6-2, 6-3 |
| Second Round | Alycia Parks | Win | 6-3, 5-7, 6-4 |
| Third Round | Petra Kvitova | Win | 6-7 (3-7), 6-3, 6-1 |
| Quarterfinals | Liudmila Samsonova | Loss | 4-6, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 15 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Katie Swan | Win | |
| Second Round | Danielle Collins | Win | |
| Third Round | Magda Linette | Win | |
| Fourth Round | Iga Swiatek | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 10 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Elina Avanesyan | Loss |
| Credit One Charleston Open | ||
| Surface: Green Clay | Date: Apr. 3 - Apr. 9 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Katherine Sebov | Win | |
| Third Round | Shelby Rogers | Win | |
| Quarterfinals | Ekaterina Alexandrova | Win | |
| Semifinals | Jessica Pegula | Win | |
| Final | Ons Jabeur | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 1 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Leylah Fernandez | Win | |
| Third Round | Ekaterina Alexandrova | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jil Teichmann | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marta Kostyuk | Win | |
| Third Round | Karolina Muchova | Loss |
| Qatar Total Energies Open | ||
| Surface: Hard | Date: Feb. 13 - Feb. 18 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Viktoriya Tomova | Win | |
| Second Round | Victoria Azarenka | Win | |
| Quarterfinals | Iga Swiatek | Loss |
| Mubadala Abu Dhabi Open | ||
| Surface: Hard | Date: Feb. 6 - Feb. 12 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marta Kostyuk | Win | |
| Quarterfinals | Shelby Rogers | Win | |
| Semifinals | Beatriz Haddad Maia | Win | |
| Final | Liudmila Samsonova | Win |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Viktoriya Tomova | Win | |
| Second Round | Claire Liu | Win | |
| Third Round | Camila Giorgi | Win | |
| Fourth Round | Aryna Sabalenka | Loss |
| Adelaide International 2 | ||
| Surface: Hard | Date: Jan. 9 - Jan. 14 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Garbine Muguruza | Win | |
| Second Round | Anna Kalinskaya | Win | |
| Quarterfinals | Caroline Garcia | Win | |
| Semifinals | Veronika Kudermetova | Win | |
| Final | Daria Kasatkina | Win |
