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| Courmayeur Ladies Open 2021 | ||
| Surface: Hard | Date: Oct. 25 - Oct. 31 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Qinwen Zheng | Win | 7-6 (7-1), 6-2 |
| Second Round | Saisai Zheng | Win | 6-3, 6-4 |
| Quarterfinals | Xinyu Wang | Win | 6-4, 6-4 |
| Semifinals | Jasmine Paolini | Win | 6-2, 6-0 |
| Final | Clara Tauson | Win | 7-6 (7-3), 6-2 |
| Tenerife Ladies Open | ||
| Surface: Hard | Date: Oct. 18 - Oct. 24 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alison Riske | Win | 6-1, 6-4 |
| Second Round | Irina-Camelia Begu | Loss | 6-4, 2-6, 6-7 (4-7) |
| BNP Paribas Open | ||
| Surface: Hard | Date: Oct. 6 - Oct. 17 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Astra Sharma | Loss | 4-6, 6-2, 3-6 |
| Chicago Fall Tennis Classic | ||
| Surface: Hard | Date: Sep. 27 - Oct. 3 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Ann Li | Loss | 3-6, 1-6 |
| Zavarovalnica Sava Portoroz | ||
| Surface: Hard | Date: Sep. 13 - Sep. 19 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Ana Konjuh | Loss | 6-0, 3-6, 2-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 30 - Sep. 12 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Garbine Muguruza | Loss | 6-7 (4-7), 6-7 (5-7) |
| National Bank Open presented by Rogers | ||
| Surface: Hard | Date: Aug. 9 - Aug. 15 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Alison Van Uytvanck | Win | 6-1, 6-2 |
| Second Round | Karolina Pliskova | Loss | 6-4, 3-6, 6-7 (2-7) |
| Mubadala Silicon Valley Classic | ||
| Surface: Hard | Date: Aug. 2 - Aug. 8 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Yulia Putintseva | Loss | 5-7, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 28 - Jul. 11 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Anastasia Potapova | Win | 6-1, 6-4 |
| Second Round | Karolina Pliskova | Loss | 2-6, 2-6 |
| Nature Valley Classic | ||
| Surface: Grass | Date: Jun. 14 - Jun. 20 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Francesca Jones | Win | 6-1, 6-3 |
| Second Round | Camila Giorgi | Win | 2-6, 6-3, 6-4 |
| Quarterfinals | Heather Watson | Loss | 4-6, 2-6 |
| Nature Valley Open | ||
| Surface: Grass | Date: Jun. 7 - Jun. 13 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Leonie Kung | Win | 7-5, 6-1 |
| Third Round | Nina Stojanovic | Loss | 3-6, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 30 - Jun. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Karolina Pliskova | Loss | 5-7, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Feb. 8 - Feb. 21 | Seed: 28 |
| Round | Opponent | W / L | Result |
| First Round | Yafan Wang | Win | 4-6, 6-3, 6-4 |
| Second Round | Nadia Podoroska | Win | 6-2, 6-2 |
| Third Round | Kaia Kanepi | Win | 5-7, 7-6 (7-2), 6-4 |
| Fourth Round | Jennifer Brady | Loss | 1-6, 5-7 |
| Yarra Valley Classic | ||
| Surface: Hard | Date: Jan. 31 - Feb. 6 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tsvetana Pironkova | Loss | 6-1, 4-6, 2-6 |
| Abu Dhabi WTA Women's Tennis Open | ||
| Surface: Hard | Date: Jan. 6 - Jan. 13 | Seed: 16 |
| Round | Opponent | W / L | Result |
| First Round | Bernarda Pera | Loss | 6-7 (10-12), 6-2, 4-6 |
