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| Guadalajara Open Akron | ||
| Surface: Hard | Date: Sep. 17 - Sep. 23 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alycia Parks | Win | 6-2, 6-2 |
| Third Round | Martina Trevisan | Loss | 7-6 (7-4), 5-7, 3-6 |
| San Diego Open | ||
| Surface: Hard | Date: Sep. 11 - Sep. 16 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anastasia Potapova | Loss | 4-6, 6-7 (4-7) |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 9 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Camila Osorio | Win | 7-5, 7-6 (7-4) |
| Second Round | Linda Noskova | Win | 7-6 (9-7), 4-6, 6-3 |
| Third Round | Marie Bouzkova | Win | 5-7, 7-6 (7-5), 6-3 |
| Fourth Round | Qinwen Zheng | Loss | 2-6, 4-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 20 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anhelina Kalinina | Win | 6-3, 6-7 (2-7), 7-6 (7-2) |
| Third Round | Donna Vekic | Win | 5-2 Retired |
| Quarterfinals | Aryna Sabalenka | Loss | 5-7, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 15 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Magdalena Frech | Win | |
| Second Round | Zhuoxuan Bai | Win | |
| Third Round | Bianca Andreescu | Win | |
| Fourth Round | Petra Kvitova | Win | |
| Quarterfinals | Elena Rybakina | Win | |
| Semifinals | Aryna Sabalenka | Win | |
| Final | Marketa Vondrousova | Loss |
| Rothesay International Eastbourne | ||
| Surface: Grass | Date: Jun. 25 - Jul. 1 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Jasmine Paolini | Win | |
| Second Round | Camila Giorgi | Loss |
| Bett1 Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Jule Niemeier | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 10 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Lucia Bronzetti | Win | |
| Second Round | Oceane Dodin | Win | |
| Third Round | Olga Danilovic | Win | |
| Fourth Round | Bernarda Pera | Win | |
| Quarterfinals | Beatriz Haddad Maia | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 21 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Paula Badosa | Loss |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jelena Ostapenko | Win | |
| Quarterfinals | Beatriz Haddad Maia | Win | |
| Semifinals | Iga Swiatek | Loss |
| Credit One Charleston Open | ||
| Surface: Green Clay | Date: Apr. 3 - Apr. 9 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lesia Tsurenko | Win | |
| Third Round | Caroline Dolehide | Win | |
| Quarterfinals | Anna Kalinskaya | Win | |
| Semifinals | Daria Kasatkina | Win | |
| Final | Belinda Bencic | Win |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 1 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Varvara Gracheva | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Magdalena Frech | Win | |
| Third Round | Marketa Vondrousova | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Tamara Zidansek | Win | |
| Second Round | Marketa Vondrousova | Loss |
| Adelaide International 1 | ||
| Surface: Hard | Date: Dec. 31 - Jan. 8 | Seed: 1 |
| Round | Opponent | W / L | Result |
| Second Round | Sorana Cirstea | Win | |
| Quarterfinals | Marta Kostyuk | Win | |
| Semifinals | Linda Noskova | Loss |
