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| Toray Pan Pacific Open Tennis Tournament | ||
| Surface: Hard | Date: Sep. 25 - Oct. 1 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye |
| Guadalajara Open Akron | ||
| Surface: Hard | Date: Sep. 17 - Sep. 24 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aliaksandra Sasnovich | Win | 4-6, 7-6 (7-5), 6-4 |
| Third Round | Hailey Baptiste | Win | 7-5, 6-4 |
| Quarterfinals | Victoria Azarenka | Win | 6-3, 6-4 |
| Semifinals | Maria Sakkari | Loss | 3-6, 0-6 |
| San Diego Open | ||
| Surface: Hard | Date: Sep. 11 - Sep. 16 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sloane Stephens | Win | 6-3, 3-6, 6-1 |
| Quarterfinals | Danielle Collins | Loss | 2-6, 3-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 9 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Yafan Wang | Loss | 4-6, 1-6 |
| Tennis in the Land | ||
| Surface: Hard | Date: Aug. 20 - Aug. 26 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Linda Fruhvirtova | Win | 6-3, 6-2 |
| Second Round | Peyton Stearns | Win | 7-6 (7-4), 6-3 |
| Quarterfinals | Lin Zhu | Loss | 4-6, 1-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 20 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sloane Stephens | Loss | 6-4, 4-6, 4-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marie Bouzkova | Loss | 4-6, 6-4, 2-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 15 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Katie Volynets | Win | |
| Second Round | Leylah Fernandez | Win | |
| Third Round | Marie Bouzkova | Loss |
| Rothesay International Eastbourne | ||
| Surface: Grass | Date: Jun. 25 - Jul. 1 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Madison Brengle | Win | |
| Second Round | Ana Bogdan | Win | |
| Quarterfinals | Daria Kasatkina | Loss |
| Bett1 Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Sabine Lisicki | Win | |
| Second Round | Jaimee Fourlis | Win | |
| Quarterfinals | Petra Kvitova | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 10 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Xiyu Wang | Win | |
| Second Round | Anna Blinkova | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 9 - May 21 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ana Bogdan | Win | |
| Third Round | Camila Osorio | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 25 - May 6 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yulia Putintseva | Win | |
| Third Round | Mayar Sherif | Loss |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tatjana Maria | Win | |
| Quarterfinals | Anastasia Potapova | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 1 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Sorana Cirstea | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dalma Galfi | Win | |
| Third Round | Leylah Fernandez | Win | |
| Fourth Round | Sorana Cirstea | Loss |
| Abierto GNP Seguros | ||
| Surface: Hard | Date: Feb. 27 - Mar. 5 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Kaja Juvan | Win | |
| Second Round | Nuria Parrizas Diaz | Win | |
| Quarterfinals | Mayar Sherif | Win | |
| Semifinals | Elise Mertens | Win | |
| Final | Donna Vekic | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Madison Keys | Loss |
| Qatar Total Energies Open | ||
| Surface: Hard | Date: Feb. 13 - Feb. 18 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Karolina Muchova | Win | |
| Quarterfinals | Maria Sakkari | Loss |
| Open 6ème Sens Métropole de Lyon | ||
| Surface: Hard | Date: Jan. 30 - Feb. 5 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Tereza Martincova | Win | |
| Second Round | Alison Van Uytvanck | Win | |
| Semifinals | Camila Osorio | Win | |
| Final | Alycia Parks | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Katherine Sebov | Win | |
| Second Round | Leylah Fernandez | Win | |
| Third Round | Laura Siegemund | Win | |
| Fourth Round | Magda Linette | Loss |
| Adelaide International 2 | ||
| Surface: Hard | Date: Jan. 9 - Jan. 14 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Katerina Siniakova | Win | |
| Quarterfinals | Belinda Bencic | Loss |
