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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Emilio Nava | Win | 7-6 (7-5), 3-6, 6-4, 7-6(7-5) |
| Second Round | Zhizhen Zhang | Loss | 4-6, 7-5, 2-6, 6-0, 2-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Max Purcell | Loss | 4-6, 6-3, 4-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jiri Lehecka | Win | 7-6 (8-6), 6-4 |
| Third Round | Alejandro Davidovich Fokina | Loss | 6-7 (4-7), 6-4, 6-7 (4-7) |
| Hamburg European Open | ||
| Surface: Red Clay | Date: Jul. 24 - Jul. 30 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Sebastian Baez | Win | 6-3, 1-6, 6-3 |
| Second Round | Cristian Garin | Win | 1-6, 6-2, 6-2 |
| Quarterfinals | Arthur Fils | Loss | 0-6, 4-6 |
| Nordea Open | ||
| Surface: Clay | Date: Jul. 17 - Jul. 23 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alexander Shevchenko | Win | |
| Quarterfinals | Sebastian Ofner | Win | |
| Semifinals | Lorenzo Musetti | Win | |
| Final | Andrey Rublev | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Laurent Lokoli | Win | |
| Second Round | Liam Broady | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Elias Ymer | Win | |
| Second Round | Giulio Zeppieri | Win | |
| Third Round | Zhizhen Zhang | Win | |
| Fourth Round | Nicolas Jarry | Win | |
| Quarterfinals | Holger Rune | Win | |
| Semifinals | Alexander Zverev | Win | |
| Final | Novak Djokovic | Loss |
| Gonet Geneva Open | ||
| Surface: Clay | Date: May 21 - May 27 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | J.J. Wolf | Win | |
| Quarterfinals | Nicolas Jarry | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Arthur Rinderknech | Win | |
| Third Round | Alexander Bublik | Win | |
| Fourth Round | Laslo Djere | Win | |
| Quarterfinals | Francisco Cerundolo | Win | |
| Semifinals | Holger Rune | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Matteo Arnaldi | Loss |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ben Shelton | Win | |
| Third Round | Francisco Cerundolo | Loss |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Botic Van De Zandschulp | Win | |
| Third Round | Jan-Lennard Struff | Loss |
| Millennium Estoril Open | ||
| Surface: Red Clay | Date: Apr. 3 - Apr. 9 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Joao Sousa | Win | |
| Quarterfinals | Sebastian Baez | Win | |
| Semifinals | Quentin Halys | Win | |
| Final | Miomir Kecmanovic | Win |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ilya Ivashka | Win | |
| Third Round | Botic Van De Zandschulp | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Diego Schwartzman | Win | |
| Third Round | Cristian Garin | Loss |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Feb. 26 - Mar. 4 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Guido Andreozzi | Win | |
| Second Round | Taro Daniel | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Tomas Machac | Win | |
| Second Round | Jenson Brooksby | Loss |
| ASB Classic | ||
| Surface: Hard | Date: Jan. 9 - Jan. 14 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Laslo Djere | Loss |
