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| China Open | ||
| Surface: Hard | Date: Sep. 28 - Oct. 4 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Nicolas Jarry |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Milos Raonic | Win | 6-2, 6-3, 6-4 |
| Second Round | Dominic Stricker | Loss | 5-7, 7-6 (7-2), 7-6 (7-5), 6-7 (6-8), 3-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ben Shelton | Win | 7-6 (7-3), 7-6 (7-2) |
| Third Round | Hubert Hurkacz | Loss | 3-6, 4-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Gael Monfils | Loss | 4-6, 3-6 |
| Abierto de Tenis Mifel | ||
| Surface: Hard | Date: Aug. 1 - Aug. 6 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | John Isner | Win | 6-2, 6-4 |
| Quarterfinals | Nicolas Jarry | Win | 6-7 (6-8), 7-6 (7-4), 6-2 |
| Semifinals | Borna Coric | Win | 6-3, 6-2 |
| Final | Alex De Minaur | Win | 6-3, 6-4 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Dominic Thiem | Win | |
| Second Round | Andy Murray | Win | |
| Third Round | Laslo Djere | Win | |
| Fourth Round | Christopher Eubanks | Loss |
| Mallorca Championships | ||
| Surface: Grass | Date: Jun. 25 - Jul. 1 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yannick Hanfmann | Loss |
| Terra Wortmann Open | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Gregoire Barrere | Win | |
| Second Round | Nicolas Jarry | Loss |
| Boss Open | ||
| Surface: Grass | Date: Jun. 12 - Jun. 18 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Richard Gasquet | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Jiri Vesely | Win | |
| Second Round | Roberto Carballes Baena | Win | |
| Third Round | Diego Schwartzman | Win | |
| Fourth Round | Sebastian Ofner | Win | |
| Quarterfinals | Carlos Alcaraz | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Nuno Borges | Win | |
| Third Round | Lorenzo Sonego | Win | |
| Fourth Round | Lorenzo Musetti | Win | |
| Quarterfinals | Borna Coric | Win | |
| Semifinals | Daniil Medvedev | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dominic Thiem | Win | |
| Third Round | Sebastian Baez | Win | |
| Fourth Round | Bernabe Zapata Miralles | Win | |
| Quarterfinals | Jan-Lennard Struff | Loss |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Pedro Cachin | Win | |
| Third Round | Denis Shapovalov | Win | |
| Quarterfinals | Alex De Minaur | Win | |
| Semifinals | Lorenzo Musetti | Win | |
| Final | Carlos Alcaraz | Loss |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Benjamin Bonzi | Win | |
| Third Round | Nicolas Jarry | Win | |
| Quarterfinals | Taylor Fritz | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Richard Gasquet | Win | |
| Third Round | Cristian Garin | Win | |
| Fourth Round | Karen Khachanov | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jordan Thompson | Loss |
| ABN Amro World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Emil Ruusuvuori | Win | |
| Second Round | Jannik Sinner | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Quentin Halys | Win | |
| Second Round | Rinky Hijikata | Win | |
| Third Round | Tallon Griekspoor | Win | |
| Fourth Round | Jannik Sinner | Win | |
| Quarterfinals | Jiri Lehecka | Win | |
| Semifinals | Karen Khachanov | Win | |
| Final | Novak Djokovic | Loss |
