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| US Open | ||
| Surface: Hard | Date: Aug. 29 - Sep. 11 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Brandon Holt | Loss | 7-6 (7-3), 6-7 (1-7), 3-6, 4-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 14 - Aug. 21 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Sebastian Baez | Win | |
| Second Round | Nick Kyrgios | Win | |
| Third Round | Andrey Rublev | Win | |
| Quarterfinals | Daniil Medvedev | Loss |
| Open de la Banque Nationale presentee par Rogers | ||
| Surface: Hard | Date: Aug. 8 - Aug. 14 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Andy Murray | Win | |
| Second Round | Frances Tiafoe | Win | |
| Third Round | Daniel Evans | Loss |
| Citi Open | ||
| Surface: Hard | Date: Aug. 1 - Aug. 7 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alexei Popyrin | Win | |
| Third Round | Daniel Evans | Loss |
| Wimbledon | ||
| Surface: Grass | Date: Jun. 27 - Jul. 10 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Lorenzo Musetti | Win | |
| Second Round | Alastair Gray | Win | |
| Third Round | Alex Molcan | Win | |
| Fourth Round | Jason Kubler | Win | |
| Quarterfinals | Rafael Nadal | Loss |
| Rothesay International Eastbourne | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Thiago Monteiro | Win | |
| Quarterfinals | Alexander Bublik | Win | |
| Semifinals | Alex De Minaur | Win | |
| Final | Maxime Cressy | Win |
| cinch Championships | ||
| Surface: Grass | Date: Jun. 13 - Jun. 19 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Jack Draper | Loss |
| Libema Open | ||
| Surface: Grass | Date: Jun. 6 - Jun. 12 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tim Van Rijthoven | Loss |
| Roland Garros | ||
| Surface: Red Clay | Date: May 22 - Jun. 5 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Santiago Fa Rodriguez Taverna | Win | |
| Second Round | Bernabe Zapata Miralles | Loss |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 10 - Apr. 17 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Lucas Catarina | Win | |
| Second Round | Marin Cilic | Win | |
| Third Round | Sebastian Korda | Win | |
| Quarterfinals | Alejandro Davidovich Fokina | Loss |
| Fayez Sarofim & Co. US Men's Clay Court Championship | ||
| Surface: Clay | Date: Apr. 4 - Apr. 10 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alejandro Tabilo | Win | |
| Quarterfinals | Cristian Garin | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 3 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mikhail Kukushkin | Win | |
| Third Round | Tommy Paul | Win | |
| Fourth Round | Miomir Kecmanovic | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 20 | Seed: 20 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kamil Majchrzak | Win | |
| Third Round | Jaume Munar | Win | |
| Fourth Round | Alex De Minaur | Win | |
| Quarterfinals | Miomir Kecmanovic | Win | |
| Semifinals | Andrey Rublev | Win | |
| Final | Rafael Nadal | Win |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Feb. 21 - Feb. 26 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Adrian Mannarino | Win | |
| Second Round | Yoshihito Nishioka | Loss |
| Dallas Open | ||
| Surface: Hard | Date: Feb. 7 - Feb. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Jack Sock | Win | |
| Quarterfinals | Marcos Giron | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 17 - Jan. 30 | Seed: 20 |
| Round | Opponent | W / L | Result |
| First Round | Maximilian Marterer | Win | |
| Second Round | Frances Tiafoe | Win | |
| Third Round | Roberto Bautista Agut | Win | |
| Fourth Round | Stefanos Tsitsipas | Loss |
