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| China Open | ||
| Surface: Hard | Date: Sep. 28 - Oct. 4 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Lorenzo Musetti |
| Zhuhai Championships | ||
| Surface: Hard | Date: Sep. 20 - Sep. 26 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alex Bolt | Win | 6-4, 6-4 |
| Quarterfinals | Mackenzie McDonald | Win | 4-6, 6-4, 6-4 |
| Semifinals | Sebastian Korda | Win | 7-5, 6-4 |
| Final | Yoshihito Nishioka | Win | 7-6 (7-2), 6-1 |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Michael Mmoh | Loss | 2-6, 4-6, 2-6 |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Constant Lestienne | Win | |
| Second Round | Radu Albot | Win | |
| Third Round | Thanasi Kokkinakis | Win | |
| Fourth Round | Lorenzo Sonego | Win | |
| Quarterfinals | Novak Djokovic | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Gregoire Barrere | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Thiago Monteiro | Win | |
| Third Round | Roberto Bautista Agut | Win | |
| Fourth Round | Andrey Rublev | Win | |
| Quarterfinals | Carlos Alcaraz | Loss |
| Barcelona Open Banc Sabadell | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Nicolas Jarry | Win | |
| Third Round | Daniel Evans | Loss |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Alejandro Davidovich Fokina | Win | |
| Second Round | Ilya Ivashka | Win | |
| Third Round | Andrey Rublev | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 14 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tomas Martin Etcheverry | Win | |
| Third Round | Jiri Lehecka | Win | |
| Fourth Round | Stefanos Tsitsipas | Win | |
| Quarterfinals | Francisco Cerundolo | Win | |
| Semifinals | Daniil Medvedev | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Oscar Otte | Win | |
| Third Round | Alejandro Davidovich Fokina | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 27 - Mar. 4 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Botic Van De Zandschulp | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 18 |
| Round | Opponent | W / L | Result |
| First Round | Bernabe Zapata Miralles | Win | |
| Second Round | Jason Kubler | Win | |
| Third Round | Frances Tiafoe | Win | |
| Fourth Round | Yoshihito Nishioka | Win | |
| Quarterfinals | Sebastian Korda | Win | |
| Semifinals | Stefanos Tsitsipas | Loss |
| Adelaide International 2 | ||
| Surface: Hard | Date: Jan. 9 - Jan. 14 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marc-Andrea Huesler | Win | |
| Quarterfinals | Jack Draper | Loss |
| Adelaide International 1 | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Pedro Cachin | Win | |
| Second Round | Jack Draper | Win | |
| Quarterfinals | Daniil Medvedev | Loss |
