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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Alexandre Muller | Win | 6-0, 6-2, 6-3 |
| Second Round | Bernabe Zapata Miralles | Win | 6-4, 6-1, 6-1 |
| Third Round | Laslo Djere | Win | 4-6, 4-6, 6-1, 6-1, 6-3 |
| Fourth Round | Borna Gojo | Win | 6-2, 7-5, 6-4 |
| Quarterfinals | Taylor Fritz | Win | 6-1, 6-4, 6-4 |
| Semifinals | Ben Shelton | Win | 6-3, 6-2, 7-6 (7-4) |
| Final | Daniil Medvedev | Win | 6-3, 7-6 (7-5), 6-3 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alejandro Davidovich Fokina | Win | 6-4, 0-0 Retired |
| Third Round | Gael Monfils | Win | 6-3, 6-2 |
| Quarterfinals | Taylor Fritz | Win | 6-0, 6-4 |
| Semifinals | Alexander Zverev | Win | 7-6 (7-5), 7-5 |
| Final | Carlos Alcaraz | Win | 5-7, 7-6 (9-7), 7-6 (7-4) |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Pedro Cachin | Win | |
| Second Round | Jordan Thompson | Win | |
| Third Round | Stan Wawrinka | Win | |
| Fourth Round | Hubert Hurkacz | Win | |
| Quarterfinals | Andrey Rublev | Win | |
| Semifinals | Jannik Sinner | Win | |
| Final | Carlos Alcaraz | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Aleksandar Kovacevic | Win | |
| Second Round | Marton Fucsovics | Win | |
| Third Round | Alejandro Davidovich Fokina | Win | |
| Fourth Round | Juan Pablo Varillas | Win | |
| Quarterfinals | Karen Khachanov | Win | |
| Semifinals | Carlos Alcaraz | Win | |
| Final | Casper Ruud | Win |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Tomas Martin Etcheverry | Win | |
| Third Round | Grigor Dimitrov | Win | |
| Fourth Round | Cameron Norrie | Win | |
| Quarterfinals | Holger Rune | Loss |
| Banja Luka Open | ||
| Surface: Clay | Date: Apr. 17 - Apr. 23 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Luca Van Assche | Win | |
| Quarterfinals | Dusan Lajovic | Loss |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ivan Gakhov | Win | |
| Third Round | Lorenzo Musetti | Loss |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 27 - Mar. 4 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Tomas Machac | Win | |
| Second Round | Tallon Griekspoor | Win | |
| Quarterfinals | Hubert Hurkacz | Win | |
| Semifinals | Daniil Medvedev | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Roberto Carballes Baena | Win | |
| Second Round | Enzo Couacaud | Win | |
| Third Round | Grigor Dimitrov | Win | |
| Fourth Round | Alex De Minaur | Win | |
| Quarterfinals | Andrey Rublev | Win | |
| Semifinals | Tommy Paul | Win | |
| Final | Stefanos Tsitsipas | Win |
| Adelaide International 1 | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Constant Lestienne | Win | |
| Second Round | Quentin Halys | Win | |
| Quarterfinals | Denis Shapovalov | Win | |
| Semifinals | Daniil Medvedev | Win | |
| Final | Sebastian Korda | Win |
