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| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Roberto Carballes Baena | Loss | 3-6, 6-4, 3-6, 2-6 |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mackenzie McDonald | Loss | 4-6, 0-2 Retired |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marcos Giron | Loss | 2-6, 6-4, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | George Loffhagen | Win | |
| Second Round | Roberto Carballes Baena | Win | |
| Third Round | Alejandro Davidovich Fokina | Win | |
| Fourth Round | Grigor Dimitrov | Win | |
| Quarterfinals | Carlos Alcaraz | Loss |
| Cinch Championships | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Maxime Cressy | Win | |
| Second Round | Ryan Peniston | Win | |
| Quarterfinals | Lorenzo Musetti | Win | |
| Semifinals | Alex De Minaur | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Christopher Eubanks | Win | |
| Second Round | Gael Monfils | Win | |
| Third Round | Genaro Alberto Olivieri | Win | |
| Fourth Round | Francisco Cerundolo | Win | |
| Quarterfinals | Casper Ruud | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Arthur Fils | Win | |
| Third Round | Fabio Fognini | Win | |
| Fourth Round | Alexei Popyrin | Win | |
| Quarterfinals | Novak Djokovic | Win | |
| Semifinals | Casper Ruud | Win | |
| Final | Daniil Medvedev | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alexander Bublik | Win | |
| Third Round | Alejandro Davidovich Fokina | Loss |
| BMW Open by American Express | ||
| Surface: Red Clay | Date: Apr. 17 - Apr. 23 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Yannick Hanfmann | Win | |
| Quarterfinals | Cristian Garin | Win | |
| Semifinals | Christopher O'Connell | Win | |
| Final | Botic Van De Zandschulp | Win |
| Rolex Monte-Carlo Masters | ||
| Surface: Clay | Date: Apr. 9 - Apr. 16 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Dominic Thiem | Win | |
| Third Round | Matteo Berrettini | Win | |
| Quarterfinals | Daniil Medvedev | Win | |
| Semifinals | Jannik Sinner | Win | |
| Final | Andrey Rublev | Loss |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 22 - Apr. 2 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marton Fucsovics | Win | |
| Third Round | Diego Schwartzman | Win | |
| Fourth Round | Taylor Fritz | Loss |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 8 - Mar. 19 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mackenzie McDonald | Win | |
| Third Round | Stan Wawrinka | Loss |
| Abierto Mexicano Telcel presentado por HSBC | ||
| Surface: Hard | Date: Feb. 26 - Mar. 4 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Ben Shelton | Win | |
| Second Round | Nuno Borges | Win | |
| Quarterfinals | Matteo Berrettini | Win | |
| Semifinals | Alex De Minaur | Loss |
| ABN Amro World Tennis Tournament | ||
| Surface: Hard | Date: Feb. 13 - Feb. 19 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Constant Lestienne | Win | |
| Second Round | Gijs Brouwer | Loss |
| Open Sud de France | ||
| Surface: Hard | Date: Feb. 6 - Feb. 12 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marc-Andrea Huesler | Win | |
| Quarterfinals | Gregoire Barrere | Win | |
| Semifinals | Maxime Cressy | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 9 |
| Round | Opponent | W / L | Result |
| First Round | Filip Krajinovic | Win | |
| Second Round | Maxime Cressy | Win | |
| Third Round | Ugo Humbert | Win | |
| Fourth Round | Andrey Rublev | Loss |
| Adelaide International 1 | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Yoshihito Nishioka | Loss |
