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| Astana Open | ||
| Surface: Hard | Date: Sep. 27 - Oct. 3 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Alexei Popyrin |
| Zhuhai Championships | ||
| Surface: Hard | Date: Sep. 20 - Sep. 26 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alexandre Muller | Win | 6-1, 2-6, 6-3 |
| Quarterfinals | Tomas Martin Etcheverry | Win | 6-1, 6-2 |
| Semifinals | Karen Khachanov | Loss | 5-7, 4-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 28 - Sep. 10 | Seed: 31 |
| Round | Opponent | W / L | Result |
| First Round | Marton Fucsovics | Loss | 6-7 (4-7), 6-4, 6-7 (1-7), 6-4, 4-6 |
| Winston-Salem Open | ||
| Surface: Hard | Date: Aug. 20 - Aug. 26 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Benjamin Bonzi | Win | 6-2, 6-3 |
| Third Round | Marton Fucsovics | Win | 7-6 (7-5), 6-3 |
| Quarterfinals | Richard Gasquet | Win | 4-6, 6-1, 7-6 (9-7) |
| Semifinals | Jiri Lehecka | Loss |
| Western & Southern Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Borna Coric | Loss | 6-7 (5-7), 4-6 |
| Omnium National Bank presented by Rogers | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Tomas Martin Etcheverry | Win | 6-3, 6-2 |
| Second Round | Aleksandar Vukic | Loss | 3-6, 6-4, 6-7 (5-7) |
| Citi Open | ||
| Surface: Hard | Date: Jul. 31 - Aug. 6 | Seed: 8 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alexander Shevchenko | Loss | 7-5, 6-7 (4-7), 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 22 |
| Round | Opponent | W / L | Result |
| First Round | Jiri Vesely | Loss |
| Cinch Championships | ||
| Surface: Grass | Date: Jun. 19 - Jun. 25 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Daniel Evans | Win | |
| Second Round | Frances Tiafoe | Win | |
| Quarterfinals | Cameron Norrie | Win | |
| Semifinals | Carlos Alcaraz | Loss |
| French Open | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 24 |
| Round | Opponent | W / L | Result |
| First Round | Mackenzie McDonald | Win | |
| Second Round | Sebastian Ofner | Loss |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 10 - May 21 | Seed: 22 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Roman Safiullin | Loss |
| Mutua Madrid Open | ||
| Surface: Hard | Date: Apr. 26 - May 7 | Seed: 22 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Hugo Grenier | Loss |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 29 |
| Round | Opponent | W / L | Result |
| First Round | Cristian Garin | Win | |
| Second Round | Yosuke Watanuki | Win | |
| Third Round | Daniil Medvedev | Win | |
| Fourth Round | Hubert Hurkacz | Win | |
| Quarterfinals | Karen Khachanov | Loss |
| Adelaide International 1 | ||
| Surface: Hard | Date: Jan. 1 - Jan. 8 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Andy Murray | Win | |
| Second Round | Roberto Bautista Agut | Win | |
| Quarterfinals | Jannik Sinner | Win | |
| Semifinals | Yoshihito Nishioka | Win | |
| Final | Novak Djokovic | Loss |
