Roster
| No. | Name | Pos | B/T | Status | Ht | Wt | Born | Birthplace |
| 60 | Pedro Avila | P | R/R | Active | 5-11 | 210 | 1/14/1997 | Caracas, Venezuela |
| 28 | José Azocar | RF | R/R | Active | 5-11 | 189 | 5/11/1996 | Sucre, Venezuela |
| 58 | Scott Barlow | P | R/R | Active | 6-3 | 215 | 12/18/1992 | New London, Connecticut |
| 17 | Matthew Batten | 2B | R/R | Active | 5-11 | 194 | 6/22/1995 | Shelton, Connecticut |
| 2 | Xander Bogaerts | SS | R/R | Active | 6-2 | 218 | 10/1/1992 | Oranjestad, Aruba |
| 12 | Luis Campusano | C | R/R | Active | 5-11 | 232 | 9/29/1998 | Augusta, Georgia |
| 73 | Drew Carlton | P | R/R | on 60-day IL | 6-1 | 207 | 9/8/1995 | Lakeland, Florida |
| 14 | Matt Carpenter | 3B | L/R | on 10-day IL | 6-4 | 210 | 11/26/1985 | Galveston, Texas |
| 91 | Ji Man Choi | 1B | L/R | Active | 6-1 | 260 | 5/19/1991 | Incheon, South Korea |
| 24 | Garrett Cooper | 1B | R/R | Active | 6-5 | 235 | 12/25/1990 | Torrance, California |
| 59 | Tom Cosgrove | P | L/L | Active | 6-2 | 190 | 6/14/1996 | New York, New York |
| 9 | Jake Cronenworth | 2B | L/R | on 10-day IL | 6-0 | 187 | 1/21/1994 | St. Clair, Michigan |
| 11 | Yu Darvish | P | R/R | on 15-day IL | 6-5 | 216 | 8/16/1986 | Osaka, Japan |
| 40 | Jose Espada | P | R/R | Active | 6-0 | 170 | 2/22/1997 | Ponce, Puerto Rico |
| 66 | Luís García | P | R/R | Active | 6-2 | 240 | 1/30/1987 | Santo Domingo, DR |
| 1 | Trent Grisham | CF | L/L | Active | 5-11 | 224 | 11/1/1996 | Burleson, Texas |
| 71 | Josh Hader | P | L/L | Active | 6-3 | 180 | 4/7/1994 | Millersville, Maryland |
| 41 | Rich Hill | P | L/L | Active | 6-5 | 221 | 3/11/1980 | Boston, Massachusetts |
| 25 | Tim Hill | P | R/L | on 60-day IL | 6-4 | 200 | 2/10/1990 | Mission Hills, California |
| 68 | Alek Jacob | P | L/R | on 60-day IL | 6-3 | 190 | 6/16/1998 | Spokane, Washington |
| 56 | Ray Kerr | P | L/L | Active | 6-3 | 185 | 9/10/1994 | Sacramento, California |
| 7 | Ha-Seong Kim | 2B | R/R | Active | 5-9 | 168 | 10/17/1995 | Bucheon, South Korea |
| 33 | Reiss Knehr | P | L/R | on 60-day IL | 6-2 | 205 | 11/3/1996 | Manhasset, New York |
| 67 | Seth Lugo | P | R/R | Active | 6-4 | 225 | 11/17/1989 | Shreveport, Louisiana |
| 13 | Manny Machado | 3B | R/R | Active | 6-3 | 218 | 7/6/1992 | Miami, Florida |
| 21 | Nick Martinez | P | L/R | Active | 6-1 | 200 | 8/5/1990 | Miami, Florida |
| 44 | Joe Musgrove | P | R/R | on 15-day IL | 6-5 | 235 | 12/4/1992 | El Cajon, California |
| 15 | Drew Pomeranz | P | R/L | on 60-day IL | 6-5 | 246 | 11/22/1988 | Collierville, Tennessee |
| 10 | Jurickson Profar | SS | S/R | Active | 6-0 | 184 | 2/20/1993 | Willemstad, Netherlands Antilles |
| 5 | Eguy Rosario | SS | R/R | Active | 5-9 | 150 | 8/25/1999 | Juan Baron, DR |
| 99 | Gary Sánchez | C | R/R | on 60-day IL | 6-2 | 230 | 12/2/1992 | Santo Domingo, DR |
| 4 | Blake Snell | P | L/L | Active | 6-4 | 225 | 12/4/1992 | Seattle, Washington |
| 22 | Juan Soto | LF | L/L | Active | 6-1 | 220 | 10/25/1998 | Santo Domingo, DR |
| 75 | Robert Suarez | P | R/R | Active | 6-2 | 210 | 3/1/1991 | Bolivar, Venezuela |
| 29 | Brett Sullivan | C | L/R | Active | 6-1 | 195 | 2/24/1994 | Stockton, California |
| 23 | Fernando Tatis Jr. | RF | R/R | Active | 6-3 | 217 | 1/2/1999 | San Pedro de Macoris, DR |
| 52 | Michael Wacha | P | R/R | Active | 6-6 | 215 | 7/1/1991 | Iowa City, Iowa |
| 61 | Matt Waldron | P | R/R | Active | 6-2 | 185 | 9/26/1996 | Omaha, Nebraska |
| 36 | Steven Wilson | P | R/R | on 15-day IL | 6-3 | 221 | 8/24/1994 | Littleton, Colorado |
Manager: Bob Melvin
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