Roster
| No. | Name | Pos | B/T | Status | Ht | Wt | Born | Birthplace |
| 41 | Logan Allen | P | R/L | on 15-day IL | 6-0 | 190 | 9/5/1998 | Altamonte Springs, Florida |
| 13 | Gabriel Arias | SS | R/R | on 10-day IL | 6-1 | 201 | 2/27/2000 | La Victoria, Venezuela |
| 61 | Tanner Bibee | P | R/R | on 60-day IL | 6-2 | 205 | 3/5/1999 | Mission Viejo, California |
| 57 | Shane Bieber | P | R/R | Active | 6-3 | 200 | 5/31/1995 | Orange, California |
| 17 | Will Brennan | CF | L/L | Active | 6-0 | 200 | 2/2/1998 | Colorado Springs, Colorado |
| 56 | Kole Calhoun | RF | L/L | Active | 5-10 | 210 | 10/14/1987 | Tempe, Arizona |
| 48 | Emmanuel Clase | P | R/R | Active | 6-2 | 206 | 3/18/1998 | Rio San Juan, DR |
| 44 | Xzavion Curry | P | R/R | Active | 6-0 | 195 | 7/27/1998 | Orangeburg, South Carolina |
| 62 | Enyel De Los Santos | P | R/R | Active | 6-3 | 235 | 12/25/1995 | San Pedro de Macoris, DR |
| 2 | Tyler Freeman | SS | R/R | Active | 6-0 | 165 | 5/21/1999 | Rancho Cucamonga, California |
| 35 | Cam Gallagher | C | R/R | Active | 6-3 | 230 | 12/6/1992 | Lancaster, Pennsylvania |
| 0 | Andrés Giménez | SS | L/R | Active | 5-11 | 161 | 9/4/1998 | Barquisimeto, Venezuela |
| 27 | Lucas Giolito | P | R/R | Active | 6-6 | 245 | 7/14/1994 | Santa Monica, California |
| 39 | Oscar Gonzalez | RF | R/R | Active | 6-4 | 240 | 1/10/1998 | Sabana Grande de Palenque, DR |
| 31 | Sam Hentges | P | L/L | Active | 6-6 | 245 | 7/18/1996 | Shoreview, Minnesota |
| 99 | James Karinchak | P | R/R | Active | 6-3 | 215 | 9/22/1995 | Newburgh, New York |
| 38 | Steven Kwan | CF | L/L | Active | 5-9 | 170 | 9/5/1997 | Los Gatos, California |
| 10 | Ramón Laureano | CF | R/R | Active | 5-11 | 203 | 7/15/1994 | Santo Domingo, DR |
| 40 | Reynaldo López | P | R/R | Active | 6-1 | 220 | 1/4/1994 | San Pedro de Macoris, DR |
| 24 | Triston McKenzie | P | R/R | Active | 6-5 | 175 | 8/2/1997 | New York, New York |
| 49 | Eli Morgan | P | R/R | Active | 5-10 | 190 | 5/13/1996 | Torrance, California |
| 23 | Bo Naylor | C | L/R | Active | 6-0 | 195 | 2/21/2000 | Mississauga, Canada |
| 22 | Josh Naylor | 1B | L/L | Active | 5-11 | 222 | 6/22/1997 | Mississauga, Canada |
| 47 | Cal Quantrill | P | L/R | Active | 6-3 | 195 | 2/10/1995 | Port Hope, Canada |
| 11 | José Ramírez | 3B | S/R | Active | 5-9 | 190 | 9/17/1992 | Bani, DR |
| 6 | Brayan Rocchio | SS | S/R | Active | 5-10 | 150 | 1/13/2001 | Caracas, Venezuela |
| 52 | Nick Sandlin | P | R/R | Active | 5-11 | 170 | 1/10/1997 | Evans, Georgia |
| 37 | Trevor Stephan | P | R/R | Active | 6-5 | 225 | 11/25/1995 | Austin, Texas |
| 7 | Myles Straw | CF | R/R | Active | 5-10 | 178 | 10/17/1994 | Garden Grove, California |
| 8 | José Tena | SS | L/R | Active | 5-10 | 160 | 3/20/2001 | San Cristobal, DR |
| 63 | Gavin Williams | P | L/R | Active | 6-5 | 250 | 7/26/1999 | Fayetteville, North Carolina |
Manager: Terry Francona
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