| Sunday, 1 May 2022 |
| Time/Result | Home | Away | Venue |
| 0-0 |
Antwerp |
Union Saint-Gilloise | Bosuilstadion |
| 0-0 |
Anderlecht |
Club Brugge | Lotto Park |
| Friday, 6 May 2022 |
| Time/Result | Home | Away | Venue |
| 2-2 |
Sporting Charleroi |
Genk | Stade du Pays de Charleroi |
| Saturday, 7 May 2022 |
| Time/Result | Home | Away | Venue |
| 1-0 |
Gent |
Mechelen | GHELAMCO-arena |
| Sunday, 8 May 2022 |
| Time/Result | Home | Away | Venue |
| 0-2 |
Union Saint-Gilloise |
Club Brugge | Stade Joseph Marien |
| 0-4 |
Antwerp |
Anderlecht | Bosuilstadion |
| Tuesday, 10 May 2022 |
| Time/Result | Home | Away | Venue |
| 1-2 |
Mechelen |
Gent | AFAS-stadion Achter de Kazerne |
| 3-2 |
Genk |
Sporting Charleroi | Cegeka Arena |
| Wednesday, 11 May 2022 |
| Time/Result | Home | Away | Venue |
| 1-0 |
Club Brugge |
Union Saint-Gilloise | Jan Breydelstadion |
| Thursday, 12 May 2022 |
| Time/Result | Home | Away | Venue |
| 2-1 |
Anderlecht |
Antwerp | Lotto Park |
| Saturday, 14 May 2022 |
| Time/Result | Home | Away | Venue |
| 3-2 |
Sporting Charleroi |
Mechelen | Stade du Pays de Charleroi |
| Sunday, 15 May 2022 |
| Time/Result | Home | Away | Venue |
| 1-3 |
Antwerp |
Club Brugge | Bosuilstadion |
| 0-2 |
Genk |
Gent | Cegeka Arena |
| 0-2 |
Anderlecht |
Union Saint-Gilloise | Lotto Park |
| Saturday, 21 May 2022 |
| Time/Result | Home | Away | Venue |
| 11:45 AM PT12:45 PM MT1:45 PM CT2:45 PM ET18:45 GMT19:45 18:45 6:45 PM 20:45 KSA5:45 AM AET0:15 (+1) IST2:15 PM VEN22:45 UAE2:45 AM SST2:45 1:45 11:45 AM MST12:45 PM CST1:45 PM EST14:45 ET13:45 15:45 BRT14:45 1:45 PM CT |
Gent |
Sporting Charleroi | GHELAMCO-arena |
| 11:45 AM PT12:45 PM MT1:45 PM CT2:45 PM ET18:45 GMT19:45 18:45 6:45 PM 20:45 KSA5:45 AM AET0:15 (+1) IST2:15 PM VEN22:45 UAE2:45 AM SST2:45 1:45 11:45 AM MST12:45 PM CST1:45 PM EST14:45 ET13:45 15:45 BRT14:45 1:45 PM CT |
Mechelen |
Genk | AFAS-stadion Achter de Kazerne |
| Sunday, 22 May 2022 |
| Time/Result | Home | Away | Venue |
| 7:00 AM PT8:00 AM MT9:00 AM CT10:00 AM ET14:00 GMT15:00 14:00 2:00 PM 16:00 KSA1:00 AM AET19:30 IST9:30 AM VEN18:00 UAE10:00 PM SST22:00 21:00 7:00 AM MST8:00 AM CST9:00 AM EST10:00 ET9:00 11:00 BRT10:00 9:00 AM CT |
Union Saint-Gilloise |
Antwerp | Stade Joseph Marien |
| 9:30 AM PT10:30 AM MT11:30 AM CT12:30 PM ET16:30 GMT17:30 16:30 4:30 PM 18:30 KSA3:30 AM AET22:00 IST12:00 PM VEN20:30 UAE12:30 AM SST0:30 23:30 9:30 AM MST10:30 AM CST11:30 AM EST12:30 ET11:30 13:30 BRT12:30 11:30 AM CT |
Club Brugge |
Anderlecht | Jan Breydelstadion |
| Sunday, 29 May 2022 |
| Time/Result | Home | Away | Venue |
| - |
Gent |
Antwerp | |
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