| Friday, 11 September 2020 |
| Time/Result | Home | Away | Venue |
| 2-1 |
AS Eupen |
Gent | Stadion am Kehrweg |
| Saturday, 12 September 2020 |
| Time/Result | Home | Away | Venue |
| 0-1 |
Mechelen |
KV Oostende | AFAS-stadion Achter de Kazerne |
| 1-0 |
OH Leuven |
Standard Liege | King Power at Den Dreef Stadion |
| 4-1 |
Club Brugge |
Waasland-Beveren | Jan Breydelstadion |
| Sunday, 13 September 2020 |
| Time/Result | Home | Away | Venue |
| 2-0 |
Anderlecht |
Cercle Brugge | Lotto Park |
| 2-3 |
Sint-Truiden |
Antwerp | Stayen |
| 0-2 |
Zulte-Waregem |
Sporting Charleroi | Regenboogstadion |
| 3-0 |
Kortrijk |
Excel Mouscron | Guldensporenstadion |
| Monday, 14 September 2020 |
| Time/Result | Home | Away | Venue |
| 5-2 |
Beerschot |
Genk | Olympisch Stadion |
| Friday, 18 September 2020 |
| Time/Result | Home | Away | Venue |
| 3-1 |
Sporting Charleroi |
Beerschot | Stade du Pays de Charleroi |
| Saturday, 19 September 2020 |
| Time/Result | Home | Away | Venue |
| 3-1 |
KV Oostende |
OH Leuven | Diaz Arena |
| 0-1 |
Excel Mouscron |
Gent | Stade Le Canonnier |
| 2-4 |
Waasland-Beveren |
Anderlecht | Freethielstadion |
| Sunday, 20 September 2020 |
| Time/Result | Home | Away | Venue |
| 0-6 |
Zulte-Waregem |
Club Brugge | Regenboogstadion |
| 2-1 |
Standard Liege |
Kortrijk | Stade Maurice Dufrasne |
| 3-1 |
Genk |
Mechelen | Luminus Arena |
| 2-2 |
Antwerp |
AS Eupen | Bosuilstadion |
| Monday, 21 September 2020 |
| Time/Result | Home | Away | Venue |
| 3-0 |
Cercle Brugge |
Sint-Truiden | Jan Breydelstadion |
| Friday, 25 September 2020 |
| Time/Result | Home | Away | Venue |
| 1-3 |
Kortrijk |
Antwerp | Guldensporenstadion |
| Saturday, 26 September 2020 |
| Time/Result | Home | Away | Venue |
| 3-2 |
Beerschot |
Waasland-Beveren | Olympisch Stadion |
| 2-0 |
Mechelen |
Sint-Truiden | AFAS-stadion Achter de Kazerne |
| 2-3 |
Gent |
OH Leuven | GHELAMCO-arena |
| Sunday, 27 September 2020 |
| Time/Result | Home | Away | Venue |
| 2-2 |
Standard Liege |
Zulte-Waregem | Stade Maurice Dufrasne |
| 1-1 |
Anderlecht |
AS Eupen | Lotto Park |
| 2-1 |
Club Brugge |
Cercle Brugge | Jan Breydelstadion |
| 1-1 |
Excel Mouscron |
Sporting Charleroi | Stade Le Canonnier |
| Monday, 28 September 2020 |
| Time/Result | Home | Away | Venue |
| 2-2 |
Genk |
KV Oostende | Luminus Arena |
@STATS_Football
